Dr. Connors reacts from The Rhino antidote he was previously working on and turns into The Lizard; Realizing this, he runs away but is spotted by his son Billy; The Lizard plots his human conquest and plans to defeat Spider-Man.
Printed: Jan 1967
Writers: Stan Lee
Art: John Romita Sr.
Cover: John Romita Sr.
- 2nd appearance of Curt Connors as the Lizard
