Aunt May falls deathly ill on Peter's first day of college. Meanwhile, the Master Planner is stealing scientific gadgets.
Printed: Dec 1965
Writers: Stan Lee
Art: Steve Ditko
Cover: Steve Ditko
- 1st appearance of Gwen Stacy
- 1st appearance of Harry Osborn
- 1st appearance of Miles Warren, later becomes the Jackal
- First time Doctor Octopus is referred to as the Master Planner
